Chauges in Ventricular Volume, Wall Thickness and Wall Stress During Progression of Left Ventricular Dysfuncthu

To assess the long-term changes in cardiac function iu N tomatic patients with severe left veatricuiar dysfunction, left ventricular (clneangiography) and right ventricular (radionuelide angiography) function were assesxd at baseline in 49 patients enrolled in the prevention arm of the Studies of Left Ventricular Dysfuoction. After an average follow-up period of 12.4 months, 30 patients (11 randomized to the placebo group and 19 to the enalapril group) could be restudied to assess the progression of ventricular dysfnnction. After 1 year of follow-up, the changes in beart rate, left ventricular end=diastolic and systolic pressure and right ventricular volumes were comparable in both groups. However, there were modest but opposite changes in left ventricular end-diastolic volome (+9 ml/m* with placebo vs. -10 ml/m* with